ONCOLOGY LETTERS, vol.27, no.6, pp.1-8, 2024 (SCI-Expanded)
In the present study, antiproliferative and anticancer
effects of Valamor (VLM), which contains the active compo‑
nent ribociclib, and DPQ, a poly(ADP‑ribose) polymerase
1 inhibitor, alone and in combination were evaluated in the
MCF‑7 and MDA‑MB‑231 breast cancer cell lines in vitro.
VLM was applied at concentrations of 40, 80 and 160 µg/ml,
and DPQ was used at concentrations of 3, 6 and 9 µg/ml. The
proliferation rate, cell index obtained from the real‑time cell
analysis system, mitosis activity, bromodeoxyuridine cell
proliferation and caspase activity parameters were deter‑
mined. In conclusion, the results obtained from cell kinetics
parameters demonstrated the anticancer and antiproliferative
effects of the combination of VLM and DPQ on breast cancer
cells.