Prevalence of thyroid dysfunctions in prediabetes


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Satman İ. , Boztepe H., Alagöl F., Dinççağ N. , Karşıdağ K. , Yılmaz M. T. , ...More

American Diabetes Association 75th Anniversary Scientific Sessions, Massachusetts, United States Of America, 5 - 09 June 2015, vol.64, no.1, pp.436

  • Publication Type: Conference Paper / Summary Text
  • Volume: 64
  • City: Massachusetts
  • Country: United States Of America
  • Page Numbers: pp.436

Abstract

Satman 09-E/1679-P

Category: 09-E Epidemiology –Other

 

Prevalence of Thyroid Dysfunctions in Prediabetes

 

Satman I1, Boztepe H1, Alagol F1, Dinccag N1, Karsidag K1, Yilmaz MT1, Tutuncu Y1, Kalaca S2, Colak Ozbey N1, TURDEP-II Study Group.

1Istanbul University, Istanbul Medical Faculty, Dept. Internal Medicine, Div.

Endocrinol & Metabolism; 2Marmara University Medical Faculty, Dept. Public Health, Istanbul – Turkey.

 

Using data from the recent adult population-based survey in Turkey (n=26,499, 63% female) we aimed to evaluate the thyroid status of individuals with different categories of prediabetes including Isolated IFG (n=3,123), Isolated IGT (n=1,663), Combined IFG+IGT (n=1,705), and High Risk A1C Group (n=6,696).

Although the mean (SEM) serum concentrations of FT4 and TSH did not differ across the groups, in the combined IFG+IGT group mean Anti-TPO level was numerically, and Anti-Tg level was remarkably higher than the other groups (p=0.003). This was not changed when the data were adjusted for age, gender, BMI, lipid profile, and known thyroid diseases. Anti-Tg levels were positively correlated with OGTT-2hPG and negatively correlated with fasting insulin.

The prevalence of overt and subclinical hypo- and hyperthyroidism, and positive Anti-TPO and positive Anti-Tg antibodies are shown in the Table.

 

Prediabetes category

Prevalence of thyroid dysfunctions (%)

Hyperthyroidism

Hypothyroidism

Anti-TPO (+)

Anti-Tg (+)

Overt

Subclinical

Overt

Subclinical

Isolated IFG

0.5

0.5

0.9

3.4

11.7

13.5

Isolated IGT

0.8

0.6

1.4

3.1

11.8

13.8

Combined IFG+IGT

0.6

0.9

1.5

4.2

14.4

16.3

High Risk A1C

0.5

0.6

1.6

3.2

11.7

13.6

 

In terms of individual dysfunctions, there was no difference across the prediabetes categories except higher frequency of positive Anti-Tg (p<0.001). However, of the combined IFG+IGT group, 21.6% had at least one thyroid dysfunction, and this was significantly higher than in the other categories (Isolated IFG: 17, Isolated IGT: 17.7, and High Risk A1C Group: 17.6%, p<0.001).

In conclusion, thyroid diseases are common among persons with prediabetes. Anti-Tg but not Anti-TPO is associated with glucose metabolism. Combined IFG+IGT category may be the most vulnerable group.

This study is funded by IU-BAP (project no. 6417).