Atıf İçin Kopyala
Unlucerci Y., Bekpmar S., Seferoglu G.
ACTA DIABETOLOGICA, cilt.37, sa.2, ss.71-76, 2000 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
37
Sayı:
2
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Basım Tarihi:
2000
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Doi Numarası:
10.1007/s005920070022
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Dergi Adı:
ACTA DIABETOLOGICA
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Sayfa Sayıları:
ss.71-76
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İstanbul Üniversitesi Adresli:
Evet
Özet
In the present study, we investigated whether the ameliorating effect of aminoguanidine on diabetes-related proteinuria and nephropathy is associated with glomerular basement membrane heparan sulphate contents. STZ-induced diabetic rats developed proteinuria (at the tenth week: diabetic rats, 713 +/- 418 mg protein per millimole creatinine; control rats, <30) and increased urinary heparan sulphate excretion (diabetic rats, 1400 +/- 83 g/mmol creatinine; control rats, 41 +/- 13; p < 0.001), suggesting loss of glomerular basement membrane charge. Aminoguanidine treatment of diabetic rats diminished urinary heparan sulphate levels (196 +/- 52), suggesting high incorporation of heparan sulphate-associated charge into glomerular basement membrane. Aminoguanidine administration to diabetic rats also relatively improved proteinuria (456 +/- 255). It is concluded that aminoguanidine treatment has a relative beneficial effect by restoring the diabetes-induced change in renal basement membrane heparan sulphate levels.