The effects of N-acetyl cysteine treatment and nitric oxide synthase inhibition on oxidative stress induced by E-coli endotoxin

Mutlu-Turkoglu U., Tamer-Toptani S., Oztezcan S., Uysal M., Toker G.

BIOCHEMICAL ARCHIVES, cilt.14, ss.33-41, 1998 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 14 Konu: 1
  • Basım Tarihi: 1998
  • Sayfa Sayıları: ss.33-41


In the present study, we have examined the effects of N-acetyl cysteine (NAG) on hepatic lipid peroxidation and glutathione levels in lipopolysaccharide (LPS) and N-nitro-L-arginine (L-NAME) treated rats. LPS treatment to rats resulted in increased lipid peroxide levels and decreased glutathione (GSH) content in the liver homogenate and mitochondria. NAC plus L-NAME administration attenuated all the abnormalities caused by LPS. In conclusion, it has been suggested that NAC may have some beneficial effects in LPS + L-NAME treated rats.