Synthesis, characterization and primary antituberculosis activity evaluation of 4-(3-coumarinyl)-3-benzyl-4-thiazolin-2-one benzylidenehydrazones

Gursoy A., Karali N. L.

TURKISH JOURNAL OF CHEMISTRY, cilt.27, sa.5, ss.545-551, 2003 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 5
  • Basım Tarihi: 2003
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.545-551
  • İstanbul Üniversitesi Adresli: Evet

Özet

In this study a new series of 4-(3-coumarinyl)-3-benzyl-4-thiazolin-2-one benzylidenehydrazones 3a-t was synthesized. Structures of the title compounds Were elucidated by elemental analyses and spectrometric data (IR, H-1-NMR, C-13-NMR and EIMS). 3a-t were evaluated for antituberculosis activity against Mycobacterium tuberculosis H37Rv in BACTEC 12B medium using the BACTEC 460 radiometric system.