Mycobacterium tuberculosis infections after renal transplantation


Apaydin S. , Altiparmak M. R. , Serdengecti K., Ataman R., Ozturk R. , Erek E.

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, cilt.32, ss.501-505, 2000 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 32 Konu: 5
  • Basım Tarihi: 2000
  • Dergi Adı: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES
  • Sayfa Sayıları: ss.501-505

Özet

The incidence of tuberculosis was found to be 5.8% (16/274) in 274 kidney graft recipients in our centre between 1986 and 1998, The kidney recipients were evaluated retrospectively. A total of 51 recipients received isoniazid prophylaxis for 6 months. The prevalence of tuberculosis was found similar (6% vs. 8,8%, p = 0.15) between recipients with prophylaxis and no prophylaxis, Eight patients were recipients of cadaveric donor kidneys and 8 were recipients of living donor kidneys. Lungs were the most frequently affected site, as in the normal population. M, tuberculosis grew in 7 patients. In 5 patients, M. tuberculosis was also detected on direct microscopy and polymerase chain reaction. In 4 patients, diagnosis was made on clinical grounds and later confirmed by positive response to therapy. In 8 patients, invasive procedures were performed for diagnosis. Five patients had miliary tuberculosis at the time of diagnosis. In 3 patients dissemination occurred during follow-up. Nine patients responded to anti-tuberculous therapy while still preserving their graft function, 1 patient rejected the graft while under treatment and returned to haemodialysis. Five patients (31%) died. Since the risk of dissemination of tuberculosis is high in these patients, anti-tuberculous therapy should be started whenever clinical findings suggestive of tuberculosis are present, even in the absence of any microbiological and/or histological evidence.