Right vs Left Colon Cancers Have Comparable Survival: a Decade's Experience


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Keskin M., Sivrikoz E., Yegen G., Bayraktar A., Kulle C. B., Bugra D., ...More

INDIAN JOURNAL OF SURGERY, vol.82, no.2, pp.134-141, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 82 Issue: 2
  • Publication Date: 2020
  • Doi Number: 10.1007/s12262-019-01900-9
  • Journal Name: INDIAN JOURNAL OF SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, Veterinary Science Database
  • Page Numbers: pp.134-141
  • Keywords: Central vascular ligation, Tumor location, Colon cancer, Laparoscopy, COMPLETE MESOCOLIC EXCISION, LAPAROSCOPIC-ASSISTED SURGERY, COUNCIL CLASICC TRIAL, ACUTE-PHASE RESPONSE, COLORECTAL-CANCER, OPEN COLECTOMY, FOLLOW-UP, RESECTION, EPIDEMIOLOGY, DIFFERENCE
  • Istanbul University Affiliated: Yes

Abstract

The aim of this study is to compare survival rates between right and left colon cancers following curative intent oncologic resection. The data of right- (between cecum and proximal two-thirds of the transverse colon) and left-sided (between distal one-third of the transverse colon and distal sigmoid colon) colon cancer patients, operated with curative intent including central vascular ligation between January 2005 and 2015, were recorded in a prospectively compiled database. Epidemiologic and clinical characteristics (laparoscopic resection, multivisceral resection, lymph node yield, metastatic lymph node yield, pathologic stage, duration of operation), early post-operative results, and overall 5-year survival rates were abstracted. A total of 426 patients were included. There were no differences in epidemiologic and clinical characteristics between two groups (p > 0.05), except a higher median lymph node yield in right-sided colon cancers (31 vs 24, p < 0.001). Cox regression analysis identified no differences in overall 5-year survival rates between right (76.9%) and left colon (76.4%) cancers (p = 0.752). In right-sided colon cancer group, 5-year overall survival was significantly higher with laparoscopic resection (60.5% vs 78.9%, p = 0.008). There were no significant differences in left-sided colon cancer group per surgical approach (p = 0.357). Curative intent oncologic resection with central vascular ligation provided similar overall 5-year survival rates in right- vs left-sided colon cancers. Laparoscopic resection provided a significantly increased 5-year overall survival in right colon cancer group.