Diapin (R): A food supplement with diverse therapeutic potentials

Creative Commons License

Magaji U. F., Boyaci S., Bulbul U., Akca S., SAÇAN Ö., SAÇAN Ö.

ISTANBUL JOURNAL OF PHARMACY, sa.3, ss.302-310, 2022 (ESCI, TRDizin)

Özet

Background and Aims: For many centuries herbs and spices have traditionally been used to treat or manage a variety of dis-eases. The formulation of food supplements containing single or multiple herbs or spices is now popular. These formulations provide biochemical, pharmacological and medicinal benefits due to their diverse phytochemical constituents. Methods: In the present study, Diapin (R) - a food supplement containing Olea europaea L. leaves extract, Cinnamomum cassia (L.) J. Presl stem extract, Nigella sativa L. seed oil, Cocos nucifera L. oil and vitamin D3 - dissolved in absolute ethanol was evaluated for alpha-amylase, alpha-glucosidase, acetylcholinesterase, elastase, neuraminidase, adenosine deaminase and arginase inhibitory activity. Results: The supplement strongly inhibited neuraminidase (IC50 = 0.272 +/- 0.007 mg/mL), while adenosine deaminase, ace-tylcholinesterase, elastase and arginase were moderately inhibited (with an IC50 of 4.562 +/- 0.052, 5.396 +/- 0.563, 5.783 +/- 0.058 and 6.800 +/- 0.067 mg/mL respectively). The less inhibition activity was on alpha-amylase and alpha-glucosidase (IC50 = 9.593 +/- 0.582 and 14.010 +/- 2.280 mg/mL respectively). Conclusion: The pharmacological activities of Diapin (R) can be attributed to its opulent phytochemical composition. The pres-ent findings support the folkloric claim of Diapin (R) supplement having antidiabetic, anticancer, anti-inflammatory, antimicro-bial, anti-ageing, and immune bolstering properties, in addition to the mitigation of Alzheimer's disease and the alleviation of neurological dysfunction.