Acute non-alcoholic caffeinated beverage consumption as a trigger for cryptogenic ischemic stroke in the young: findings from the SECRETO study

Ferdinand, Phillip; Bajpai, Ram; von Sarnowski, Bettina; Ylikotila, Pauli; Zedde, Marialuisa; Sarkanen, Tomi; Ryliskiene, Kristina; Martinez-Majander, Nicolas; Tulkki, Lauri; Licenik, Radim; Kõrv, Janika; Kõrv, Liisa; Pezzini, Alessandro; Fonseca, Ana; Martinez-Sanchez, Patricia; Amaya-Pascasio, Laura; Yesilot, NİLÜFER; Waje-Andreassen, Ulrike; Fromm, Annette; Huhtakangas, Juha; Junttola, Ulla; Jäkälä, Pekka; Kantanen, Anne-Mari; Redfors, Petra; Sinisalo, Juha; Gerdts, Eva; Tatlisumak, Turgut; Roffe, Christine; Putaala, Jukka

doi:10.1007/s00415-026-13882-2

Acute non-alcoholic caffeinated beverage consumption as a trigger for cryptogenic ischemic stroke in the young: findings from the SECRETO study

Ferdinand P., Bajpai R., von Sarnowski B., Ylikotila P., Zedde M., Sarkanen T., ...Daha Fazla

Journal of Neurology, cilt.273, sa.7, 2026 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 273 Sayı: 7
Basım Tarihi: 2026
Doi Numarası: 10.1007/s00415-026-13882-2
Dergi Adı: Journal of Neurology
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE, Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest), Pharma Collection (ProQuest)
Anahtar Kelimeler: Case-crossover analysis, Cryptogenic ischemic stroke, Triggers of ischemic stroke, Young ischemic stroke
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
İstanbul Üniversitesi Adresli: Evet

Özet

Introduction: Cryptogenic ischemic stroke (CIS) is responsible for the increase in young ischemic strokes. We investigated non-alcoholic caffeinated beverages as a trigger for young CIS, in a large multi-center, case–control study. Methods: In Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Etiology, Triggers, and Outcome (SECRETO; NCT01934725), patients 18–49 years old suffering first ever CIS were recruited within 2 weeks of symptom onset. A structured questionnaire obtained information on coffee, tea, and cola consumption in the last 12 months, usual daily consumption, consumption 24 h preceding stroke and timing of the last consumption prior to stroke. Case-crossover analysis was performed using the Mantel–Haenszel method. Results: 598 CIS patients (54.7% male, mean age 39.4 [standard deviation 8.2]) were analyzed. Case-crossover analysis found association with coffee consumption in the 1-h (relative risk [RR] 1.73, 95% confidence interval [CI] 1.06–2.83) and 2-h (RR 2.15, 95%CI 1.40–3.29) hazard periods, tea consumption in the 1-h (RR 3.93, 95%CI 1.04–14.95) and 2- hour (RR 4.89, 95%CI 1.92–12.50) hazard periods and cola consumption (RR 3.70, 95%CI 1.18–11.62) in the 2-h hazard period. Sub-group analysis in the 2-h hazard period found coffee consumption was associated in both sexes and age groups, high-risk patent foramen ovale (PFO), mild/moderate stress and both low-/high-risk factor burden. Tea consumption was associated in both sexes and age groups and those without PFO. Conclusion: Coffee, tea, and cola consumption as potential trigger factors were associated with young CIS patients within the 2-h hazard period, with coffee and tea maintaining association in several sub-groups.