Akademik Veri Yönetim Sistemi
Cumhuriyet Tıp Dergisi, cilt.43, sa.1, ss.85-89, 2021 (Hakemli Dergi)
Objective: Increased urinary excretion of uric acid has been shown to be
associated with vesicoureteral reflux (VUR). The aim of this study is
evaluate if urinary uric acid/creatinine ratio can be used as a
surrogate for renal scarring in VUR.
Method: Retrospective chart
analysis was made to identify patients who were diagnosed with VUR.
Those with secondary VUR, <3 years of age, and inadequate evaluation
were excluded. Age, gender, VUR status, dimercaptosuccinic acid (DMSA)
scintigraphy findings, presence of hypertension and microalbuminuria,
and body mass index values were noted. Uric acid, calcium and creatinine
levels for both urine and serum were measured. Urinary uric
acid/creatinine and calcium/creatinine ratios were assessed for age.
Backward logistic regression analysis was used for determining any
predictors.
Results: A total of 76 patients were eligible for the
study. Mean age was 8.2±3.7 years. There were 49 females and 27 males.
Fifty-one patients had renal scars while 25 had no scars.
Microalbuminuria was present in 22 patients. Hypertension was detected
in 5 patients. Hyperuricosuria was found in 23 patients (30.7%) while
hypercalciuria was found only in 1 patient (1.3%). There was no
correlation between urinary uric acid/creatinine and renal scarring,
microalbuminuria and hypertension. Also, no correlation was found
between urinary calcium/creatinine levels and aforementioned parameters
(p values >0.05, for all).
Conclusions: Our results indicate that
urinary uric acid/creatinine ratio would not be used as surrogate for
renal scarring in VUR.