Evaluation of obstetric outcomes and prognostic significance of graft function in kidney transplant recipient pregnancies

MADAZLI R., KAYMAK D., Alpay V., Erenel H., DİNCER M. T., SEYAHİ N.

HYPERTENSION IN PREGNANCY, vol.39, no.2, pp.89-94, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 2
  • Publication Date: 2020
  • Doi Number: 10.1080/10641955.2020.1727498
  • Journal Name: HYPERTENSION IN PREGNANCY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.89-94
  • Istanbul University Affiliated: Yes

Abstract

Objective: To evaluate obstetric and kidney outcomes in pregnancies with kidney transplantation. Methods: We retrospectively reviewed 32 singleton pregnancies in kidney transplant recipients. Obstetric outcomes were explored according to the estimated glomerular filtration rates (eGFR) of patients. Results: The incidences of fetal growth restriction, preeclampsia were 18.8% and 34.4%, respectively. There was a significant negative correlation between first-trimester eGFR and perinatal mortality (r = -0.546, p = .0.001) and composite adverse obstetric outcome (r = -0.415, p = .0.018). Conclusion: The degree of transplanted kidney function impairment at the beginning of pregnancy is the major determinant of pregnancy outcome.