Is There Increased Risk of Childhood Cancers after Assisted Reproductive Techniques?

Tugcu D., Ozhan N., Unuvar A., Karaman S., Tuna R., Bilici M., ...Daha Fazla

PEDIATRIC BLOOD & CANCER, cilt.67, 2020 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Özet
  • Cilt numarası: 67
  • Basım Tarihi: 2020
  • Dergi Adı: PEDIATRIC BLOOD & CANCER
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background and Aims: Assisted reproductive techniques (ART) have
been determined to be a risk factors for multiple pregnancy, perinatal
complications and congenital malformations in children. In this study,
we aimed to determine the role of possible risk factors for assisted
reproductive techniques in childhood malignancies.
Methods: 300 patients between the ages of 0-18 years who were
admitted to Istanbul Medical Faculty, Department of Pediatric Hema-
tology and Oncology, between 2000-2019 and 300 healthy children
between 0-14 years of age who were admitted to Departmens of Social
Pediatrics, period of May-June 2018 are included. SPSS 22.0 program was used in statistical analysis. The study was approved by the Clinical
Research Ethics Committee (17.05.2018 / 181360).
Results: The mean age of the case group was 8.3±2.1, control group
was 6.1±1.2 years. The case group consisted of 131 solid tumors and
169 leukemia-lymphoma. 17 of 300 patients in the case group were
born ART, 21 of 300 patients in the control group were born after ART,
there was no statistically significant difference (p = 0.12). Five (6.8%)
of the 73 ALL patients in the case group, two of the 38 NBL patients
(5.2%), one of 10 germ cell tumors (10%), one of 26 NHL (3.8%), one
of 50 HL (2%), one of 15 RMS (6.6%), two of 17 LCH (11.7%), one of 19
wilms tumors (5.2%), one of 8 hepatoblastomas (12,5%) were born with
ART. The patient who was diagnosed with infantile hemangioendothe-
lioma and congenital mesoblastic nephroma in the study were born as
aresultofART.
Conclusions: Our results did not support retrospectively as a possi-
ble risk factor of birth as a result of fertility treatment in children with
cancer. The rates of developing tumors in children with healthy donors
used in infertile families will also contribute to the questions between
ART and childhood tumors in the future