Glycine receptor and myelin oligodendrocyte glycoprotein antibodies in Turkish patients with neuromyelitis optica
JOURNAL OF THE NEUROLOGICAL SCIENCES, sa.1-2, ss.221-223, 2013 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2013
- Doi Numarası: 10.1016/j.jns.2013.08.034
- Dergi Adı: JOURNAL OF THE NEUROLOGICAL SCIENCES
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.221-223
- Anahtar Kelimeler: Aquaporin-4, Myelin oligodendrocyte glycoprotein, Glycine receptor, Antibody, Neuromyelitis optica, Sera, SPECTRUM, MOG
- İstanbul Üniversitesi Adresli: Evet
Özet
Background: Seronegative NMO is highly prevalent in non-Western countries implying the presence of as yet unknown antibodies (Ab). We investigated potential novel Ab in aquaporin-4 Ab (AQP-4-Ab) positive and negative NMO patients. Methods: Sera of 20 NMO patients were examined for AQP-4, myelin oligodendrocyte glycoprotein (MOG) and glycine receptor (GlyR) Ab by cell-based assays. Results: AQP-4-Ab was identified in 10 NMO patients, MOG-Ab was detected only in one AQP-4-Ab positive patient and GlyR-Ab was detected in two AQP-4-Ab negative patients. GlyR-Ab positive patients displayed simultaneous optic neuritis and transverse myelitis attacks and relatively low disability, whereas MOG and AQP-4-Ab double positive patient had a significantly increased disability. Conclusion: This study showed for the first time the presence of GlyR-Ab in Turkish NMO patients. In contrast with previous reports, MOG Ab does not appear to be a distinctive marker for Turkish AQP-4-Ab negative NMO patients. (c) 2013 Elsevier B.V. All rights reserved.