No association between methylenetetrahydrofolate reductase C677T polymorphism and breast cancer.

Hekim N., Ergen A., Yaylim I., Yilmaz H., Zeybek U., Ozturk O., ...Daha Fazla

Cell biochemistry and function, cilt.25, sa.1, ss.115-7, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 1
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1002/cbf.1274
  • Dergi Adı: Cell biochemistry and function
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.115-7
  • İstanbul Üniversitesi Adresli: Evet

Özet

Methylenetetrahydrofolate reductase (MTHFR) is an enzyme (EC 1.5.1.20), that reduces 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a carbon donor for the homocysteine to methionine conversion. MTHFR is a keyenzyme that regulates folate metabolism which has an important role in DNA synthesis, DNA repair and methylation.