INVESTIGATION OF MMP-2 AND MMP-13 IMMUNOREACTIVITY IN PLACENTA OF RATS TREATED WITH RETINOIC ACID

Kotil T., Tapul L.

JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI, vol.73, no.2, pp.46-51, 2010 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 73 Issue: 2
  • Publication Date: 2010
  • Journal Name: JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.46-51
  • Keywords: Placenta, retinoic acid, matrix metalloproteinase-2, matrix metalloproteinase-13, MATRIX-METALLOPROTEINASE (MMP)-2, RECONSTITUTED BASEMENT-MEMBRANE, HUMAN TERM DECIDUA, FETAL MEMBRANES, TISSUE INHIBITORS, CELL DIFFERENTIATION, EXPRESSION, INVASION, MATRIX-METALLOPROTEINASE-9, ENZYMES
  • Istanbul University Affiliated: Yes

Abstract

Objective: Matrix metalloproteinases (MMPs) are enzymes and play important roles at implantation by degradation of extracellular matrix. Retinoic acid (RA) is an important molecule has effects on MMP synthesis, embriyonic development and trophoblast invasion at placentation. In this study we investigated the MMP-2 and MMP-13 immunoreactivity on rat placenta treated by RA.