INVESTIGATION OF MMP-2 AND MMP-13 IMMUNOREACTIVITY IN PLACENTA OF RATS TREATED WITH RETINOIC ACID

Kotil T., Tapul L.

JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI, cilt.73, sa.2, ss.46-51, 2010 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 73 Sayı: 2
  • Basım Tarihi: 2010
  • Dergi Adı: JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.46-51
  • Anahtar Kelimeler: Placenta, retinoic acid, matrix metalloproteinase-2, matrix metalloproteinase-13, MATRIX-METALLOPROTEINASE (MMP)-2, RECONSTITUTED BASEMENT-MEMBRANE, HUMAN TERM DECIDUA, FETAL MEMBRANES, TISSUE INHIBITORS, CELL DIFFERENTIATION, EXPRESSION, INVASION, MATRIX-METALLOPROTEINASE-9, ENZYMES
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: Matrix metalloproteinases (MMPs) are enzymes and play important roles at implantation by degradation of extracellular matrix. Retinoic acid (RA) is an important molecule has effects on MMP synthesis, embriyonic development and trophoblast invasion at placentation. In this study we investigated the MMP-2 and MMP-13 immunoreactivity on rat placenta treated by RA.