PAI-1 and TNF-alpha profiles of adipose tissue in obese cardiovascular disease patients

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Gazioglu S. B., Akan G., Atalar F., Erten G.

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, cilt.8, sa.12, ss.15919-15925, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 12
  • Basım Tarihi: 2015
  • Dergi Adı: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.15919-15925
  • Anahtar Kelimeler: PAI-1, TNF-alpha, adipose tissue, cardiovascular disease, PLASMINOGEN-ACTIVATOR INHIBITOR-1, NECROSIS-FACTOR-ALPHA, INSULIN-RESISTANCE, METABOLIC SYNDROME, INFLAMMATION, EXPRESSION, RISK, FAT, ADIPONECTIN, IMPACT
  • İstanbul Üniversitesi Adresli: Evet

Özet

Obesity as a leading preventable cause of death worldwide is closely linked to cardiovascular disease (CVD). Plasma plasminogen activator inhibitor (PAI)-1, a potent inhibitor of plasminogen activation and fibrinolysis, is increased in many clinical situations associated with high incidence of CVD. In the obesity-linked elevation of PAI-1, evidence points to TNF-alpha as an important regulator of PAI-1 expression in adipose tissue. Background: This study aims to evaluate mediastinal PAI-1 and TNF-alpha mRNA levels in adipose tissues (AT) and compare serum levels in obesity with and without coronary artery disease (CAD). Patients and methods: Obese patients with (n=37) and without CAD (n=20) were included in the study. Results: The serum levels of PAI-1 and TNF-alpha were significantly higher in obese patients with CAD compared to obese patients without CAD. PAI-1 mRNA expression was significantly increased in mediastinal adipose tissue (MAT) of obese patients with CAD compared to those without CAD, TNF-alpha mRNA expressions were found to be higher in EAT (epicardial AT), MAT and SAT (subcutaneous AT) of obese patients with CAD. Conclusions: The study demonstrated a close direct relationship between TNF-alpha and PAI-1. PAI-1 mRNA expression strongly correlated positively with serum TNF-alpha in MAT, and TNF-alpha expressions with PAI-1 serum levels.