Akademik Veri Yönetim Sistemi
Medical Journal of Bakirkoy, cilt.20, sa.2, ss.104-108, 2024 (ESCI)
Objective: Chronic spontaneous urticaria (CSU) is a common skin disorder that is considered to be an autoimmune disorder in a subset of patients. Because it is not always possible to find a trigger in CSU cases, it may be thought that various cytokines may play a role in the inflammatory processes associated with CSU. One of these markers is interleukin-17 (IL-17). Methods: In this case-control study, serum IL-17 levels were measured in 50 patients with CSU and 35 healthy control subjects. Urticaria activity score (UAS-7) was used to assess disease activity. Results: Serum levels of IL-17 in patients with CSU were not significantly different from those in healthy controls [mean and median: 3.98±3.88 (3.1) vs. 4.85±2.96 (3.9) pg/mL, p=0.063]. Serum levels of IL-17 in mild CSU patients did not differ significantly from those in moderate-severe CSU patients [mean and median: 4.24±4.33 (3.3) vs. 3.1±1.13 (3) pg/mL, p=0.30]. No significant differences in IL-17 levels were observed between autologous serum tests (ASST) (+) and ASST (-) patients with similar UAS, and serum IL-17 levels of patients did not significantly differ according to sex and antinuclear antibody positivity. Conclusion: This is the first study to examine serum IL-17 levels in children with CSU. Further studies with a larger number of patients are needed to elucidate the role of IL-17 in the pathogenesis of childhood CSU.