Investigation of PhiKZ phage therapy against Pseudomonas aeruginosa in mouse pneumonia model

Can K., Aksu U., Yenen O. S.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.48, sa.3, ss.670-678, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 48 Sayı: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.3906/sag-1711-22
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.670-678
  • Anahtar Kelimeler: Phage therapy, bacterial load, Pseudomonas aeruginosa PAO1, PhiKZ phage, pneumonia, mice model, BACTERIOPHAGE THERAPY, STAPHYLOCOCCUS-AUREUS, INFECTIONS, EFFICACY, MICE, ANTIBIOTICS, SEPTICEMIA
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background/aim: The aim of this study was to investigate the effects of PhiKZ phage therapy and meropenem alone or combined treatments in a pneumonia mouse model induced by the Pseudomonas aeruginosa PAO1 strain. The cross- talk between lungs and kidneys was also determined.