Oxidative and nitrosative stress and apoptosis in the liver of rats fed on high methionine diet: Protective effect of taurine

Yalcinkaya S., Unlucerci Y., Giris M., Olgac V., Dogru-Abbasoglu S., Uysal M.

NUTRITION, cilt.25, sa.4, ss.436-444, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 4
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.nut.2008.09.017
  • Dergi Adı: NUTRITION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.436-444
  • Anahtar Kelimeler: Homocysteine, Taurine, Oxidative stress, Nitrosative stress, Apoptosis, Liver, INCREASED LIPID-PEROXIDATION, SUPPLEMENTED DIET, CASPASE-3 ACTIVATION, FOLIC-ACID, HOMOCYSTEINE, HYPERHOMOCYSTEINEMIA, PROTEIN, HEPATOTOXICITY, ATHEROSCLEROSIS, EXPRESSION
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: There are few reports about the direct toxic effects of hyperhomocysteinemia on the liver. We investigated oxidative and nitrosative stresses and apoptotic and necrotic changes in the liver of rats fed a high-methionine (HM) diet (2%, w/w) for 6 mo. We also investigated whether taurine, an antioxidant amino acid, is protective against an HM-diet-induced toxicity in the liver.