Oxidative and nitrosative stress and apoptosis in the liver of rats fed on high methionine diet: Protective effect of taurine

Yalcinkaya, Seda; Unlucerci, Yaşar; Giris, MURAT; Olgac, NECAT; Dogru-Abbasoglu, SEMRA; Uysal, Muejdat

doi:10.1016/j.nut.2008.09.017

Oxidative and nitrosative stress and apoptosis in the liver of rats fed on high methionine diet: Protective effect of taurine

Yalcinkaya S., Unlucerci Y., Giris M., Olgac V., Dogru-Abbasoglu S., Uysal M.

NUTRITION, vol.25, no.4, pp.436-444, 2009 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 25 Issue: 4
Publication Date: 2009
Doi Number: 10.1016/j.nut.2008.09.017
Journal Name: NUTRITION
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.436-444
Keywords: Homocysteine, Taurine, Oxidative stress, Nitrosative stress, Apoptosis, Liver, INCREASED LIPID-PEROXIDATION, SUPPLEMENTED DIET, CASPASE-3 ACTIVATION, FOLIC-ACID, HOMOCYSTEINE, HYPERHOMOCYSTEINEMIA, PROTEIN, HEPATOTOXICITY, ATHEROSCLEROSIS, EXPRESSION
Istanbul University Affiliated: Yes

Abstract

Objective: There are few reports about the direct toxic effects of hyperhomocysteinemia on the liver. We investigated oxidative and nitrosative stresses and apoptotic and necrotic changes in the liver of rats fed a high-methionine (HM) diet (2%, w/w) for 6 mo. We also investigated whether taurine, an antioxidant amino acid, is protective against an HM-diet-induced toxicity in the liver.