The influence of nifedipine on blood-brain barrier permeability during bicuculline-induced seizures

Oztas B.

INTERNATIONAL JOURNAL OF NEUROSCIENCE, cilt.99, ss.105-112, 1999 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 99
  • Basım Tarihi: 1999
  • Doi Numarası: 10.3109/00207459908994317
  • Sayfa Sayıları: ss.105-112


The influence of the calcium channel blocker nifedipine plus bicuculline-induced seizures on the permeability of the blood-brain barrier to protein was studied in rats. Evans-blue was used as a blood-brain barrier tracer. Four groups of rats were studied. Group I: control, Group II: Nifedipine, Group III: bicuculline-induced seizure, Group IV: Nifedipine + seizure. The mean value for Evens-blue dye in the brain was found to be 0.23 +/- 0.03 mg/g in control animals and 0.32 +/- 0.06 mg/g in the group of all rats during nifedipine-induced hypotension. This difference between control and hypotensive animals was not statistically significant (p < 0.5). Mean value for Evans-blue dye in the brain was found to be 1.4 +/- 0.3 mg/g in bicuculline-induced seizure, and 0.73 +/- 0.2 mg/g in the group of nifedipine plus bicuculline-induced seizures. This difference between Group III and Group IV was found statistically significant (p < .01). The calcium channel blocker nifedipine significantly prevents the blood brain barrier disruption during bicuculline-induced seizure.