Vehicle effects on in vitro release of tiaprofenic acid from different topical formulations

Özsoy Y., GÜNGÖR S., CEVHER E.

Farmaco, vol.59, no.7, pp.563-566, 2004 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 59 Issue: 7
  • Publication Date: 2004
  • Doi Number: 10.1016/j.farmac.2004.04.006
  • Journal Name: Farmaco
  • Journal Indexes: Scopus
  • Page Numbers: pp.563-566
  • Keywords: Diffusion coefficient, In vitro release, Non-steroidal anti-inflammatory drugs, Tiaprofenic acid, Topical formulation
  • Istanbul University Affiliated: Yes

Abstract

The aim of the present study was to investigate the in vitro release properties of tiaprofenic acid (TA) from different topical vehicles. Carbopol® 940 gel, chitosan gel, two types of emulsion-based ointment formulations (o/w and w/o) and hydrophilic petrolatum USP were prepared with 2% drug content. Drug release from all vehicles through a standard cellophane membrane was evaluated by using Franz-type diffusion cells. In vitro release study results showed that the diffusion coefficients of the drug from vehicles rank according to the following order: Carbopol® 940 gel (D = 3.11 × 10-7 ± 0.54 cm2/s) > chitosan gel (D = 0.27 × 10-7 ± 0.08 cm2/s) > emulsion-based ointment (o/w) (D = 0.18 × 10-7 ± 0.05 cm2/s) > emulsion-based ointment (w/o) (D = 0.13 × 10 -7 ± 0.02 cm2/s) > hydrophilic petrolatum USP (D = 0.02 × 10-7 ± 0.01 cm2/s). Carbopol ® 940 gel base showed significantly higher drug release than other vehicles (P < 0.001). These results indicated that Carbopol ® 940 gel base is a good candidate for the topical delivery of TA, giving significantly higher drug release than the other vehicles. © 2004 Elsevier SAS. All rights reserved.