Reduction of edema and infarction by Memantine and MK-801 after focal cerebral ischaemia and reperfusion in rat.

Gorgulu A., Kins T., Cobanoglu S., Unal F. E., Izgi N., Yanik B., ...Daha Fazla

Acta neurochirurgica, cilt.142, sa.11, ss.1287-92, 2000 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 142 Sayı: 11
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1007/s007010070027
  • Dergi Adı: Acta neurochirurgica
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1287-92
  • Anahtar Kelimeler: edema, focal cerebral ischemia, memantine, reperfusion, METHYL-D-ASPARTATE, BRAIN EDEMA, ARTERY OCCLUSION, GLUTAMATE, ANTAGONIST, ISCHEMIA, AMANTADINE, POTENT, DAMAGE, BLOCK
  • İstanbul Üniversitesi Adresli: Evet

Özet

N-methyl-D-aspartate (NMDA) receptor antagonists have been found to be protective after cerebral ischemia. However most of these drugs have limited value as neuroprotectives in clinical therapy because of their side effects. Memantine is a noncompetitive NMDA receptor antagonist and it has been used for the treatment of various cerebral disorders with relatively few side effects. We investigated the beneficial effects of Memantine and compared its effect with MK-801 in a temporary focal cerebral ischemia model.