Atıf İçin Kopyala
Gorgulu A., Kins T., Cobanoglu S., Unal F. E., Izgi N., Yanik B., ...Daha Fazla
Acta neurochirurgica, cilt.142, sa.11, ss.1287-92, 2000 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
142
Sayı:
11
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Basım Tarihi:
2000
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Doi Numarası:
10.1007/s007010070027
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Dergi Adı:
Acta neurochirurgica
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Sayfa Sayıları:
ss.1287-92
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Anahtar Kelimeler:
edema, focal cerebral ischemia, memantine, reperfusion, METHYL-D-ASPARTATE, BRAIN EDEMA, ARTERY OCCLUSION, GLUTAMATE, ANTAGONIST, ISCHEMIA, AMANTADINE, POTENT, DAMAGE, BLOCK
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İstanbul Üniversitesi Adresli:
Evet
Özet
N-methyl-D-aspartate (NMDA) receptor antagonists have been found to be protective after cerebral ischemia. However most of these drugs have limited value as neuroprotectives in clinical therapy because of their side effects. Memantine is a noncompetitive NMDA receptor antagonist and it has been used for the treatment of various cerebral disorders with relatively few side effects. We investigated the beneficial effects of Memantine and compared its effect with MK-801 in a temporary focal cerebral ischemia model.