Gender-specific associations of the APOA1-75G > A polymorphism with several metabolic syndrome components in Turkish adults


Coban N., Onat A., Guclu-Geyik F., Komurcu-Bayrak E., Can G., Erginel-Unaltuna N.

CLINICA CHIMICA ACTA, vol.431, pp.244-249, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 431
  • Publication Date: 2014
  • Doi Number: 10.1016/j.cca.2014.01.017
  • Journal Name: CLINICA CHIMICA ACTA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.244-249
  • Keywords: Apolipoprotein A1, Polymorphism, HDL-C, Atherogenic dyslipidemia, Blood pressure, APOLIPOPROTEIN-A-I, HIGH-DENSITY-LIPOPROTEIN, AIV GENE-CLUSTER, PLASMA APO-AI, PROMOTER REGION, HDL-CHOLESTEROL, RISK, DEFINITION, DISEASE, LOCI
  • Istanbul University Affiliated: Yes

Abstract

Background: Variations in the apolipoprotein A-1 (APOA1) gene, a determinant of plasma high-density lipoprotein cholesterol (HDL-C) and apoA-I levels, may contribute to cardiovascular diseases. We evaluated the effects of a promoter polymorphism (-75G>A) in the APOA1 gene on metabolic syndrome (MetS) components in a Turkish population sample.