Gender-specific associations of the APOA1-75G > A polymorphism with several metabolic syndrome components in Turkish adults

Coban N., Onat A., Guclu-Geyik F., Komurcu-Bayrak E., Can G., Erginel-Unaltuna N.

CLINICA CHIMICA ACTA, cilt.431, ss.244-249, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 431
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.cca.2014.01.017
  • Dergi Adı: CLINICA CHIMICA ACTA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.244-249
  • Anahtar Kelimeler: Apolipoprotein A1, Polymorphism, HDL-C, Atherogenic dyslipidemia, Blood pressure, APOLIPOPROTEIN-A-I, HIGH-DENSITY-LIPOPROTEIN, AIV GENE-CLUSTER, PLASMA APO-AI, PROMOTER REGION, HDL-CHOLESTEROL, RISK, DEFINITION, DISEASE, LOCI
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: Variations in the apolipoprotein A-1 (APOA1) gene, a determinant of plasma high-density lipoprotein cholesterol (HDL-C) and apoA-I levels, may contribute to cardiovascular diseases. We evaluated the effects of a promoter polymorphism (-75G>A) in the APOA1 gene on metabolic syndrome (MetS) components in a Turkish population sample.