Preparation of Electrochemical Sensor for Paracetamol Detection Based on a New Piperazine Substituted Triazole-Coumarin Hybrid Doped PEDOT Modified Flexible HOPG Electrode


ARVAS B., YAZAR AYDOĞAN S., ARVAS M. B., EĞLENCE BAKIR S., ŞAHİN M., YOLAÇAN Ç.

ECS Journal of Solid State Science and Technology, vol.12, no.7, 2023 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 7
  • Publication Date: 2023
  • Doi Number: 10.1149/2162-8777/ace2eb
  • Journal Name: ECS Journal of Solid State Science and Technology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Compendex, INSPEC
  • Keywords: electrochemistry, flexible electrode, paracetamol, pedot, pharmaceutical analysis, sensor
  • Istanbul University Affiliated: Yes

Abstract

This study includes the electrochemical determination of paracetamol (PC), using novel piperazine substituted triazole-coumarin hybrids doped PEDOT coated highly oriented pyrolytic graphite (HOPG) electrode. For the electrochemical determination of paracetamol, using an electrode prepared by a one step electropolymerization of the new triazole-tethered piperazine coumarin hybrid doped PEDOT conductive polymer on the HOPG substrate was mentioned. The electrodes were characterized by FT-IR, SEM and XRD analysis. The possible interference effects of Ascorbic acid, Uric acid, Dopamine, Glucose and Caffeine were investigated by chronoamperometry in the presence of paracetamol. The sensor (PEDOT-MC1/HOPG-10 Scan) has a high sensitivity to paracetamol, with a limit of detection (LOD) of 0.312 μm and a RSD % of 1.22 (S/N = 3). In addition, real sample analyzes were performed on pharmaceutical samples for PC determination using the prepared sensor (PEDOT-MC1/HOPG-10 Scan). The novelty of this paper is the use of new piperazine substituted triazole-coumarin hybrid doped PEDOT material for the first time in the literature, as well as a new electrode substrate material for the determination of paracetamol and the use of HOPG (Highly oriented pyrolytic graphite), which exhibits higher electroanalytical performance than other carbon-based materials.