Transforming growth factor-beta 2 polymorphism and systemic lupus erythematosus

Alansari A., Hajeer A., Teh L., Bayat A., Mysercough A., Gul A., ...Daha Fazla

JOURNAL OF RHEUMATOLOGY, cilt.29, sa.6, ss.1189-1191, 2002 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 6
  • Basım Tarihi: 2002
  • Dergi Adı: JOURNAL OF RHEUMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1189-1191
  • Anahtar Kelimeler: systemic lupus erythematosus, transforming growth factor, beta 2, SUSCEPTIBILITY GENES, PARP ALLELES, TGF-BETA, MICE, INDUCTION, LINKAGE
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective. To determine whether transforming growth factor-beta2 (TGF-beta2) gene polymorphism is associated with systemic lupus erythematosus (SLE) susceptibility. TGF-beta is a multifunctional family of cytokines important in tissue repair, inflammation and immunoregulation. SLE is thought to be a T cell dependent autoimmune disorder with T cell dysfunction. Due to its known suppressive effects on interleukin 2 dependent T cell growth, TGF-beta2 is considered to be a candidate SLE susceptibility gene. Furthermore, SLE has been linked with a region to which the TGF-B2 gene has been mapped.