Hydroxycloroquine-induced oxidative stress on sciatic nerve and muscle tissue of rats: A stereological and biochemical study

Uzar E., Özay R., Evliyaoglu O., Aktaş A., Ulkay M. B., Uyar M. E., ...Daha Fazla

HUMAN & EXPERIMENTAL TOXICOLOGY, cilt.31, sa.10, ss.1066-1073, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 10
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1177/0960327111433183
  • Dergi Adı: HUMAN & EXPERIMENTAL TOXICOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1066-1073
  • İstanbul Üniversitesi Adresli: Evet

Özet

The aim of this study was to investigate the role of hydroxychloroquine (HCQ)-induced oxidative stress on sciatic nerve and muscle tissues of rats. The oxidant/antioxidant parameters in the sciatic nerve and muscle tissues were analyzed, and stereological analysis of the sciatic nerve was performed. Levels of malondialdehyde and nitric oxide in the tissues were significantly higher in the HCQ group than in the control group (p < 0.05). In addition, activities of superoxide dismutase and glutathione peroxidase were found to be significantly higher in the HCQ group than the control group (p < 0.05). There were significant decreases in nerve fiber diameter and myelin sheet thickness in the HCQ group compared with the control group (p < 0.05). These results revealed that HCQ might increase oxidative stress on sciatic nerve and muscle tissues of rats, which may correlate with axonal atrophy in sciatic nerves.

The aim of this study was to investigate the role of hydroxychloroquine (HCQ)-induced oxidative stress on

sciatic nerve and muscle tissues of rats. The oxidant/antioxidant parameters in the sciatic nerve and muscle

tissues were analyzed, and stereological analysis of the sciatic nerve was performed. Levels of malondialdehyde

and nitric oxide in the tissues were significantly higher in the HCQ group than in the control group (

 

p < 0.05).

In addition, activities of superoxide dismutase and glutathione peroxidase were found to be significantly higher

in the HCQ group than the control group (

 

p < 0.05). There were significant decreases in nerve fiber diameter

and myelin sheet thickness in the HCQ group compared with the control group (

 

p < 0.05). These results

revealed that HCQ might increase oxidative stress on sciatic nerve and muscle tissues of rats, which may

correlate with axonal atrophy in sciatic nerves.