Serum YKL-40 as a marker of disease activity and stricture formation in patients with Crohn's disease
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol.23, no.8, 2008 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 23 Issue: 8
- Publication Date: 2008
- Doi Number: 10.1111/j.1440-1746.2007.05121.x
- Journal Name: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Istanbul University Affiliated: Yes
Abstract
Background and Aim: YKL-40 is secreted by macrophages and neutrophils and is a growth factor for vascular endothelial cells and fibroblasts. Elevated serum levels of YKL-40 have been reported in patients with various inflammatory conditions and ongoing fibrosis. The aim of this study was to investigate the relationship between serum concentrations of YKL-40 and disease activity, acute phase reactants, and the presence of strictures in patients with Crohn's disease (CD).