Uvaol-28-D-(R)-pyroglutamic acid ester: a new triterpenoid compound from Circinella muscae CGMCC 3.2695 anditsactivity assessment in transgenic zebrafish

Zhang X., Jin X., Li H., Miski M., Tan X., Chen W.

Records of Natural Products, cilt.20, sa.1, 2026 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 1
  • Basım Tarihi: 2026
  • Doi Numarası: 10.25135/rnp.2508.3620
  • Dergi Adı: Records of Natural Products
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, ABI/INFORM, EMBASE
  • Anahtar Kelimeler: Circinella muscae CGMCC 3.2695, intersegmental vessel, motor neuronal axonal, transgenic zebrafish, Uvaol-28-D-(R)-pyroglutamic acid ester
  • İstanbul Üniversitesi Adresli: Evet

Özet

A novel triterpenoid compound named uvaol-28-D-(R)-protoglutamic acid ester (UPE) was obtained via microbial biotransformation of uvaol by Circinella muscae CGMCC 3.2695. Its structure was elucidated by spectroscopic and mass-spectrometric analyses, including 1D-and 2D-NMR, HR-ESI-MS, and quant. UPE administration promotes intersegmental vessel (ISV) growth and motor neuron development in transgenic zebrafish embryos in a concentration-dependent manner. Furthermore, UPE significantly restored the swimming distance in zebrafish exposed to combretastatin A-4 (CA-4), as assessed by ESOvision behavioral analysis. These findings suggest that UPE holds promise for the treatment of cardiovascular and cerebrovascular diseases.