Uvaol-28-D-(R)-pyroglutamic acid ester: a new triterpenoid compound from Circinella muscae CGMCC 3.2695 anditsactivity assessment in transgenic zebrafish
Records of Natural Products, cilt.20, sa.1, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 20 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.25135/rnp.2508.3620
- Dergi Adı: Records of Natural Products
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, ABI/INFORM, EMBASE
- Anahtar Kelimeler: Circinella muscae CGMCC 3.2695, intersegmental vessel, motor neuronal axonal, transgenic zebrafish, Uvaol-28-D-(R)-pyroglutamic acid ester
- İstanbul Üniversitesi Adresli: Evet
Özet
A novel triterpenoid compound named uvaol-28-D-(R)-protoglutamic acid ester (UPE) was obtained via microbial biotransformation of uvaol by Circinella muscae CGMCC 3.2695. Its structure was elucidated by spectroscopic and mass-spectrometric analyses, including 1D-and 2D-NMR, HR-ESI-MS, and quant. UPE administration promotes intersegmental vessel (ISV) growth and motor neuron development in transgenic zebrafish embryos in a concentration-dependent manner. Furthermore, UPE significantly restored the swimming distance in zebrafish exposed to combretastatin A-4 (CA-4), as assessed by ESOvision behavioral analysis. These findings suggest that UPE holds promise for the treatment of cardiovascular and cerebrovascular diseases.