Relationship between MCP1 (-2518A > G) gene variants and ovarian cancer in Turkish population

Attar R., Yilmaz S. G., Cakmakoglu B., Duman S., Yildirim G., Gormus U., ...More

CELLULAR AND MOLECULAR BIOLOGY, vol.63, no.8, pp.100-103, 2017 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 8
  • Publication Date: 2017
  • Doi Number: 10.14715/cmb/2017.63.8.21
  • Journal Name: CELLULAR AND MOLECULAR BIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.100-103
  • Keywords: MCP1 (-2518A > G), Single nucleotide polymorphism, Genetic variability, Case-control study, Ovarian cancer, MONOCYTE CHEMOATTRACTANT PROTEIN-1, POLYMORPHISM, SUSCEPTIBILITY, METASTASIS, CARCINOMA, DISEASE, CELLS, CCL2
  • Istanbul University Affiliated: Yes

Abstract

The monocyte chemoattractant protein-1 (MCP-1) gene polymorphism(-2518A>G) in the regulatory region of the MCP-1 protein has been reported to be associated with cancer risk. In this study we aimed to investigate the relationship of MCP-1 (-2518A>G) gene polymorphism and ovarian cancer. MCP-1 genotyping was performed using polymerase chain reaction from blood samples ofovarian cancer patient (n=56) and a control groups (n=52). There was a significant difference in MCP1 (-2518A>G) genotypes between the patient and control groups (p=0.049; x(2)=6.042). AA carriers were significantly higher in the control group (p=0.014) whereas AG genotype and G allele carriers were significantly higher in the ovarian cancer group (p=0.029, p=0.014, respectively). This study suggests that MCP-1 (-2518A>G) AG genotype and G allele could be considered as risk factor for susceptibility to ovarian cancer.