Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression

Glanville K. P., Coleman J. R., Hanscombe K. B., Euesden J., Choi S. W., Purves K. L., ...More

BIOLOGICAL PSYCHIATRY, vol.87, no.5, pp.419-430, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 87 Issue: 5
  • Publication Date: 2020
  • Doi Number: 10.1016/j.biopsych.2019.06.031
  • Journal Name: BIOLOGICAL PSYCHIATRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Psycinfo, Veterinary Science Database
  • Page Numbers: pp.419-430
  • Keywords: Autoimmune disorder, Complement, Genetic association, Human leukocyte antigen, Major depressive disorder, Major histoconnpatibility complex, GENOME-WIDE ASSOCIATION, AUTOIMMUNE-DISEASE, RISK-FACTORS, COMPLEX, IMPUTATION, INFERENCE, ANXIETY, HEALTH, LOCI
  • Istanbul University Affiliated: No

Abstract

BACKGROUND: The prevalence of depression is higher in individuals with autoimmune diseases, but the mechanisms underlying the observed comorbidities are unknown. Shared genetic etiology is a plausible explanation for the overlap, and in this study we tested whether genetic variation in the major histocompatibility complex (MHC), which is associated with risk for autoimmune diseases, is also associated with risk for depression.