Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression

Glanville K. P., Coleman J. R., Hanscombe K. B., Euesden J., Choi S. W., Purves K. L., ...Daha Fazla

BIOLOGICAL PSYCHIATRY, cilt.87, sa.5, ss.419-430, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 87 Sayı: 5
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.biopsych.2019.06.031
  • Dergi Adı: BIOLOGICAL PSYCHIATRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Psycinfo, Veterinary Science Database
  • Sayfa Sayıları: ss.419-430
  • Anahtar Kelimeler: Autoimmune disorder, Complement, Genetic association, Human leukocyte antigen, Major depressive disorder, Major histoconnpatibility complex, GENOME-WIDE ASSOCIATION, AUTOIMMUNE-DISEASE, RISK-FACTORS, COMPLEX, IMPUTATION, INFERENCE, ANXIETY, HEALTH, LOCI
  • İstanbul Üniversitesi Adresli: Hayır

Özet

BACKGROUND: The prevalence of depression is higher in individuals with autoimmune diseases, but the mechanisms underlying the observed comorbidities are unknown. Shared genetic etiology is a plausible explanation for the overlap, and in this study we tested whether genetic variation in the major histocompatibility complex (MHC), which is associated with risk for autoimmune diseases, is also associated with risk for depression.