18F-FDG-PET/CT imaging in diagnostic workup of pediatric precursor B-cell lymphoblastic lymphoma


Kroeze E., Padilla L. A., Burkhardt B., Attarbaschi A., von Mersi H., KEBUDİ R., ...More

Pediatric Blood and Cancer, vol.70, no.11, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 70 Issue: 11
  • Publication Date: 2023
  • Doi Number: 10.1002/pbc.30642
  • Journal Name: Pediatric Blood and Cancer
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, CINAHL, MEDLINE, Veterinary Science Database
  • Keywords: 18F-FDG-PET/CT, B-cell, diagnostics, imaging, lymphoblastic lymphoma, non-Hodgkin lymphoma, PET/CT
  • Istanbul University Affiliated: Yes

Abstract

18F-fluorodeoxyglucose-positron emission tomography/computed tomography (PET/CT) imaging is currently not used in standard diagnostics for B-cell precursor lymphoblastic lymphoma (BCP-LBL), and it is unknown whether PET/CT imaging would lead to agreement between detection of lesions with the gold standard imaging methods. Therefore, we performed a retrospective cohort study in which we included 32 pediatric BCP-LBL patients and determined localizations by reviewing local imaging reports. There was a disagreement between protocol-based imaging and PET/CT in 59% of the patients, and the discrepancies mostly comprise of additional lesions detected with PET/CT, typically in lymph node and bone or the absence of bone marrow involvement with PET/CT. If PET/CT was leading in determining definite stage of disease, this would lead to a different stage and therapy branch in 31% and 28% of the patients, respectively.