An HPLC Method for the Determination of Bisoprolol in Human Plasma and its Application to a Pharmacokinetic Study


Ulu S. T., Aydogmus Z.

JOURNAL OF CHROMATOGRAPHIC SCIENCE, vol.50, no.7, pp.615-619, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 7
  • Publication Date: 2012
  • Doi Number: 10.1093/chromsci/bms056
  • Journal Name: JOURNAL OF CHROMATOGRAPHIC SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.615-619
  • Istanbul University Affiliated: Yes

Abstract

A new high-performance liquid chromatographic method is described for the determination of bisoprolol in human plasma. The proposed method was based on the derivatization of bisoprolol with 4-chloro-7-nitro-2,1,3-benzoxadiazole in borate buffer at pH 9.5 to yield a fluorescent product.