An HPLC Method for the Determination of Bisoprolol in Human Plasma and its Application to a Pharmacokinetic Study
JOURNAL OF CHROMATOGRAPHIC SCIENCE, cilt.50, sa.7, ss.615-619, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 50 Sayı: 7
- Basım Tarihi: 2012
- Doi Numarası: 10.1093/chromsci/bms056
- Dergi Adı: JOURNAL OF CHROMATOGRAPHIC SCIENCE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.615-619
- İstanbul Üniversitesi Adresli: Evet
Özet
A new high-performance liquid chromatographic method is described for the determination of bisoprolol in human plasma. The proposed method was based on the derivatization of bisoprolol with 4-chloro-7-nitro-2,1,3-benzoxadiazole in borate buffer at pH 9.5 to yield a fluorescent product.