Cell-free methylation of RASSF1 and CDKN2AIP genes in the diagnosis of hepatocellular carcinoma associated with hepatitis B virus cirrhosis

Telli P., Ozturk N. B., Hakan M. T., Cavus B., Ormeci A. C., Yakut A., ...Daha Fazla

HEPATOLOGY FORUM, cilt.3, sa.3, ss.77-81, 2022 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 3 Sayı: 3
  • Basım Tarihi: 2022
  • Doi Numarası: 10.14744/hf.2022.2022.0021
  • Dergi Adı: HEPATOLOGY FORUM
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Sayfa Sayıları: ss.77-81
  • Anahtar Kelimeler: Cirrhosis, hepatitis B virus, hepatocellular carcinoma, CIRCULATING NUCLEIC-ACIDS, DNA METHYLATION, CANCER, BIOMARKERS, CPG
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background and Aim: Chronic hepatitis B virus (HBV) infection is a major cause of hepatocellular carcinoma (HCC). Circulating cell-free DNA (cfDNA) methylation of tumor suppressor genes are emerging potential biomarkers in HCC. We aimed to evaluate the cfDNA methylation status of RASSF1 and CDKN2AIP genes in patients with liver cirrhosis (LC) with or without HCC caused by HBV.