Cell-free methylation of RASSF1 and CDKN2AIP genes in the diagnosis of hepatocellular carcinoma associated with hepatitis B virus cirrhosis

Telli P., Ozturk N. B., Hakan M. T., Cavus B., Ormeci A. C., Yakut A., ...More

HEPATOLOGY FORUM, vol.3, no.3, pp.77-81, 2022 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 3 Issue: 3
  • Publication Date: 2022
  • Doi Number: 10.14744/hf.2022.2022.0021
  • Journal Name: HEPATOLOGY FORUM
  • Journal Indexes: Emerging Sources Citation Index (ESCI)
  • Page Numbers: pp.77-81
  • Keywords: Cirrhosis, hepatitis B virus, hepatocellular carcinoma, CIRCULATING NUCLEIC-ACIDS, DNA METHYLATION, CANCER, BIOMARKERS, CPG
  • Istanbul University Affiliated: Yes


Background and Aim: Chronic hepatitis B virus (HBV) infection is a major cause of hepatocellular carcinoma (HCC). Circulating cell-free DNA (cfDNA) methylation of tumor suppressor genes are emerging potential biomarkers in HCC. We aimed to evaluate the cfDNA methylation status of RASSF1 and CDKN2AIP genes in patients with liver cirrhosis (LC) with or without HCC caused by HBV.