Simvastatin induces apoptosis in human breast cancer cells: p53 and estrogen receptor independent pathway requiring signalling through JNK

Koyuturk M., Ersoz M., Altiok N.

CANCER LETTERS, vol.250, no.2, pp.220-228, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 250 Issue: 2
  • Publication Date: 2007
  • Doi Number: 10.1016/j.canlet.2006.10.009
  • Journal Name: CANCER LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.220-228
  • Istanbul University Affiliated: Yes


The effect of simvastatin, a widely used statin for the treatment of hypercholesterolemia, was investigated in the estrogen receptor (ER)-positive MCF-7, and the ER-negative MDA-MB 231 human breast cancer cell lines. Simvastatin induced cell cycle arrest and apoptosis in both cells. These effects of simvastatin were not altered by 17-beta-estradiol treatment.