Akademik Veri Yönetim Sistemi
Anatolian Journal of Clinical Investigation, cilt.5, sa.1, ss.24-32, 2011 (Scopus)
The comparison of the hyaluronic acid (HA), prolidase, haptoglobulin, apolipoprotein A1 and alfa-2 macroglobulin levels and the results of the liver needle biopsies of patients with chronic hepatitis B virus infection were examined and efficiency of these parameters in follow-up of the treatment responses were evaluated. In this study, in patients with chronic hepatitis B virus infection (CHBV), a) correlation of hyaluronic acid (HA), prolidase, haptoglobulin, apolipoprotein A1 and alfa-2 macroglobulin, ratios, with results of the liver needle biopsies, and b) efficiency of these parameters in follow-up of the treatment responses were examined. Study group consists of the 35 patients with CHBV and 21 control cases with HBV that were not histopathologically chronic. The biopsy was applied to all patients before the treatment, and to study group at the 6th month during the treatment. The average AST and HA levels were found to be higher (p<0,05 for all) for the treatment group than controls at the 0th, 3rd, 6th, and 18th months. The haptoglobulin levels showed a significant decrease in response group in the 6th month (p = 0.014, 0.015, 0.006, respectively), and a significant increase in the 12th month (p = 0.006, 0.005, 0.017). At the beginning of the treatment, a positive relation was found between fibrosis level, HA and prolidase levels. It was concluded that the HA and prolidase levels decreased significantly in the 12th month, they are tests that could be used to show and follow the fibrotic activity but, the other tests could be used to follow the treatment response.