Unrevealing the vital role of ncRNAs in Gastric Cancer chemoresistance

Kazemi A., Goodarzi M., Daneshipour K., Sarabadani H., Shahpar Z., Hajiagha B. S., ...More

Pathology Research and Practice, vol.250, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 250
  • Publication Date: 2023
  • Doi Number: 10.1016/j.prp.2023.154761
  • Journal Name: Pathology Research and Practice
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS
  • Keywords: Chemoresistance, Gastric cancer, Non-coding RNAs
  • Istanbul University Affiliated: Yes


The high incidence of gastric cancer in many nations and poor overall survival rates has remained a serious global health concern. Chemoresistance in gastric cancer is a significant issue that hinders the efficacy of available treatment options. In gastric cancer, non-coding RNAs like microRNAs, long non-coding RNAs, and circular RNAs have become effective regulators of chemoresistance. These non-coding RNAs can influence several mechanisms, including drug efflux transporters, drug metabolism, and detoxification, cancer stem cells and the epithelial-mesenchymal transition, autophagy and apoptosis, and the tumor microenvironment. In this article review, we summarize the key roles non-coding RNAs play in the chemoresistance of gastric cancer and consider how they might be used in clinical settings as markers for diagnosis and prognosis, as well as potential targets and treatment plans. We also emphasize the need for additional study and collaborations in this area and highlight the difficulties and opportunities in non-coding RNA research for gastric cancer chemoresistance. This review offers crucial insights into the intricate relationship between non-coding RNAs and chemoresistance in gastric cancer, with implications for precision oncology and personalized medicine.