Eosinophilia and hyperimmunoglobulinemia E as the presenting manifestations of Wegener's granulomatosis.

Kamali S., Kasapoglu E., Akturk F., Gul A., Inanc M., Ocal L., ...Daha Fazla

Clinical rheumatology, cilt.22, sa.4-5, ss.333-5, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 4-5
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1007/s10067-003-0725-2
  • Dergi Adı: Clinical rheumatology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.333-5
  • Anahtar Kelimeler: Wegener's granulomatosis, eosinophilia, hyperimmunoglobulinernia E, intra-alveolar haemorrhage, CHURG-STRAUSS-SYNDROME, SYSTEMIC VASCULITIS, VARIANT
  • İstanbul Üniversitesi Adresli: Evet

Özet

Eosinophilia has long been known as a hallmark of Churg-Strauss syndrome but has rarely been reported in Wegener's granulomatosis (WG). Here we describe a patient with WG who had skin, kidney and lung involvement as well as striking peripheral eosinophilia and hyperimmunoglobulinaemia E (hyper-IgE). The patient's clinical picture was complicated by intra-alveolar haemorrhage resulting in severe anaemia and respiratory failure. The pulmonary symptoms recovered completely, but the renal involvement evolved into end-stage renal failure despite intensive immunosuppressive treatment, intravenous immunoglobulin and plasmapheresis. We suggest that the presence of eosinophilia and hyper-IgE might contribute to the development of different disease patterns in WG.