Myeloid/Lymphoid Neoplasms With Eosinophilia And Specific Gene Rearrangements: A Genetic Approach Eozinofilisi ve Spesifik Gen Yeniden Düzenlenmeleri Olan Miyeloid/ Lenfoid Neoplazmalara Genetik Yaklaşım

Bayrak Tokaç A. G., Aday A.

Genel Tip Dergisi, cilt.35, sa.1, ss.219-221, 2025 (Scopus, TRDizin) identifier identifier

  • Yayın Türü: Makale / Kısa Makale
  • Cilt numarası: 35 Sayı: 1
  • Basım Tarihi: 2025
  • Doi Numarası: 10.54005/geneltip.1598254
  • Dergi Adı: Genel Tip Dergisi
  • Derginin Tarandığı İndeksler: Scopus, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.219-221
  • Anahtar Kelimeler: Eosinophilia, hematological neoplasm, myeloid/lymphoid neoplasm with eosinophilia
  • İstanbul Üniversitesi Adresli: Evet

Özet

Eosinophils are granular leukocytes derived from a pluripotent stem cell in the bone marrow. An increase in the number of eosinophils in the blood and/or tissues requires a multifaceted clinical approach. It is important to determine the cause of the increase in order to make a correct diagnosis. Myeloid/lymphoid neoplasms with eosinophilia and specific gene fusions involve abnormal tyrosine kinase or cytokine receptor activity. Due to the similarity and heterogeneity of clinical findings, there may be diagnostic confusion in this group of diseases. Confirmation of the diagnosis is possible with genetic testing. This article briefly summarises the genetic approach to myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions.