A novel thienothiophene-based “dual-responsive” probe for rapid, selective and sensitive detection of hypochlorite

Suna G., Erdemir E., Liv L., Karakus A. C., Gunturkun D., Öztürk T., ...Daha Fazla

Talanta, cilt.270, 2024 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 270
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1016/j.talanta.2023.125545
  • Dergi Adı: Talanta
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, L'Année philologique, Aerospace Database, Analytical Abstracts, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, Food Science & Technology Abstracts, Metadex, Pollution Abstracts, Veterinary Science Database, Civil Engineering Abstracts
  • Anahtar Kelimeler: Cell imaging, Cyclic voltammetry, Hypochlorite detection, Malononitrile, Thienothiophene
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: Hypochlorite/hypochlorous acid (ClO−/HOCl) is a biologically crucial reactive oxygen species (ROS), produced in living organisms and has a critical role as an antimicrobial agent in the natural defense system. However, when ClO− is produced excessively, it can lead to the oxidative damage of biomolecules, resulting in organ damage and various diseases. Therefore, it is imperative to have a straightforward, quick and reliable method for over watching the minimum amount of ClO− in different environments. Results: Herein, a new probe TTM, containing thienothiophene and malononitrile units, was developed for exceptionally selective and sensitive hypochlorite (ClO−) detection. TTM demonstrated a rapid “turn-on” fluorescence response (<30 s), naked-eye detection (colorimetric), voltammetric read-out with anodic scan, low detection limit (LOD = 0.58 μM and 1.43 μM for optical and electrochemical methods, respectively) and applicability in detecting ClO− in real water samples and living cells. Significance and novelty: This study represents one of the rare examples of a small thienothiophene-based molecule for both optical and electrochemical detections of ClO− in an aqueous medium.