AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, vol.32, no.3, pp.132-138, 2018 (SCI-Expanded)
Article / Article
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
Science Citation Index Expanded (SCI-EXPANDED), Scopus
thermosensitive, in situ gel, mucoadhesive, allergic rhinitis, mometasone furoate, intranasal corticosteroids, suspension, rat model, ovalbumin, immunoglobulin, histopathological evaluation, NASAL SPRAY, INFLAMMATION, DIAGNOSIS, EFFICACY, SYSTEMS, DROPS, PHASE, MICE
Istanbul University Affiliated:
Background: Mometasone furoate, one of the second generation intranasal corticosteroids, is currently used in suspension form due to its poor solubility. However, this is not favorable for nasal application because of the rapid elimination of the instilled drug from the nasal cavity by mucociliary clearance and delayed onset of action due to the slow dissolution of drug in suspension.