Effects of a Thermosensitive In Situ Gel Containing Mometasone Furoate on a Rat Allergic Rhinitis Model

Altuntas E., Yener G., DOĞAN R., Aksoy F., Aydin M. S., KARATAS E.

AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, cilt.32, sa.3, ss.132-138, 2018 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1177/1945892418764951
  • Dergi Adı: AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.132-138
  • Anahtar Kelimeler: thermosensitive, in situ gel, mucoadhesive, allergic rhinitis, mometasone furoate, intranasal corticosteroids, suspension, rat model, ovalbumin, immunoglobulin, histopathological evaluation, NASAL SPRAY, INFLAMMATION, DIAGNOSIS, EFFICACY, SYSTEMS, DROPS, PHASE, MICE
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: Mometasone furoate, one of the second generation intranasal corticosteroids, is currently used in suspension form due to its poor solubility. However, this is not favorable for nasal application because of the rapid elimination of the instilled drug from the nasal cavity by mucociliary clearance and delayed onset of action due to the slow dissolution of drug in suspension.