Effects of a Thermosensitive In Situ Gel Containing Mometasone Furoate on a Rat Allergic Rhinitis Model


Altuntas E. , Yener G., DOĞAN R., Aksoy F., Aydin M. S. , KARATAS E.

AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, vol.32, no.3, pp.132-138, 2018 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 3
  • Publication Date: 2018
  • Doi Number: 10.1177/1945892418764951
  • Title of Journal : AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
  • Page Numbers: pp.132-138
  • Keywords: thermosensitive, in situ gel, mucoadhesive, allergic rhinitis, mometasone furoate, intranasal corticosteroids, suspension, rat model, ovalbumin, immunoglobulin, histopathological evaluation, NASAL SPRAY, INFLAMMATION, DIAGNOSIS, EFFICACY, SYSTEMS, DROPS, PHASE, MICE

Abstract

Background: Mometasone furoate, one of the second generation intranasal corticosteroids, is currently used in suspension form due to its poor solubility. However, this is not favorable for nasal application because of the rapid elimination of the instilled drug from the nasal cavity by mucociliary clearance and delayed onset of action due to the slow dissolution of drug in suspension.