In vitro physiological effects of betahistine on cell lines from different origins

KEPEKÇİ A. H., KIĞ C., GÜNDOĞAN G. İ.

Turkish Journal of Pharmaceutical Sciences, cilt.18, sa.2, ss.140-145, 2021 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 2
  • Basım Tarihi: 2021
  • Doi Numarası: 10.4274/tjps.galenos.2020.88155
  • Dergi Adı: Turkish Journal of Pharmaceutical Sciences
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.140-145
  • Anahtar Kelimeler: Betahistine, cellular-migration, apoptotsis, proliferation, cancer, LONG-TERM, HISTAMINE, VERTIGO, DISEASE, SAFETY, ASSAY
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Objectives: Betahistine is a histamine analog commonly prescribed for symptomatic treatment of vertiginous symptoms. In vitro studies have shown that betahistine was not toxic at the prescribed doses in a nasal epithelial cell line. However, the effect of betahistine on other cell types has not been studied. In this study, we aimed to investigate some of the physiological effects of betahistine on L929 fibroblast, A549 lung cancer, human umbilical vein endothelial (HUVEC), and Ishikawa endometrial cell lines.