Specific site involvement in fixed drug eruption


Ozkaya-Bayazit E.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, cilt.49, ss.1003-1007, 2003 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 49 Konu: 6
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1016/s0190-9622(03)01588-3
  • Dergi Adı: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
  • Sayfa Sayıları: ss.1003-1007

Özet

A total of 105 patients with established fixed drug eruption (FDE) by oral provocation were evaluated with regard to a drug-related site involvement. Cotrimoxazole was the leading causative agent (63.8%), followed by naproxen sodium (23.8%), dipyrone (5.7%), oxicams (4.8%) and other rare causes (1.9%). Cotrimoxazole most frequently induced lesions on genital mucosa; naproxen and oxicams on lips; and dipyrone on trunk and extremities. Isolated FDE on male genitalia (n = 16) was exclusively because of cotrimoxazole. A highly significant association could be established between naproxen and FIDE on lips (chi-square = 28.3; corrected P = .000002). As this study represents the largest series of patients with naproxen-induced FIDE, we would suggest that naproxen should be considered as an important potential cause of FDE on lips.