Regulatory function of CD4+CD25++ T cells in patients with myasthenia gravis is associated with phenotypic changes and STAT5 signaling: 1,25-Dihydroxyvitamin D3 modulates the suppressor activity.

Alahgholi-Hajibehzad M., Oflazer P., Aysal F., Durmus H., Gulsen-Parman Y., MARX A., ...Daha Fazla

Journal of neuroimmunology, cilt.281, ss.51-60, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 281
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.jneuroim.2015.03.008
  • Dergi Adı: Journal of neuroimmunology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.51-60
  • Anahtar Kelimeler: Treg, GITR, PD-1, STAT-5, Vitamin D, LOMG, VITAMIN-D DEFICIENCY, DENDRITIC CELLS, B-CELLS, EXPRESSION, CYTOKINES, FOXP3, IL-2, TOLERANCE, MECHANISM, D-3
  • İstanbul Üniversitesi Adresli: Evet

Özet

Regulatory T cells were investigated in early-onset (EO) and late-onset (LO) myasthenia gravis patients with anti-acetylcholine receptor antibody (AChR-MG). Alterations in PD-1 and PD-L1 on CD4(+)CD25(++) (Treg) and responder T cells (Tresp, CD4(+)CD25(-)) were observed in LOMG patients. GITR was decreased on CD4(+)CD25(++) of all patients. Decrease of FOXP3 was associated with lower phosphorylation of STAT5.1,25-dihydroxyvitamin D3 (VitD3) increased suppression in co-culture with a stronger effect in patients by acting possibly both on cell groups. Changes in surface molecules and intracellular pathways contribute to the defects of Treg in non-thymomatous AChR-MG and VitD3 can have modulatory effects. (C) 2015 Elsevier B.V. All rights reserved.