EFFECTS OF ERYTHROPOIETIN PRETREATMENT ON LIVER, KIDNEY, HEART TISSUE IN PENTYLENTETRAZOL-INDUCED SEIZURES ; EVALUATION IN TERMS OF OXIDATIVE MARKERS, PROLIDASE AND SIALIC ACID

Kapucu A., Kaptan Z., Akgun Dar K., Kaleler I., Uzum G.

JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI, vol.84, no.4, pp.464-471, 2021 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 84 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.26650/iuitfd.2021.883402
  • Journal Name: JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.464-471
  • Keywords: Erythropoietin, PTZ-induced seizures, oxidative stress markers, sialic acid, prolidase, peripheral tissues, ENZYME-ACTIVITY, PENTYLENETETRAZOLE, STRESS, RAT, PREVENTS, INCREASE, INJURY, ASSAY
  • Istanbul University Affiliated: Yes

Abstract

Objective: The effects of erythropoietin (EPO) which has been frequently studied as an anti-epileptic agent, on peripheral tis-sues have not been investigated. This study investigated the ef-fects on malondialdehyde (MDA), advanced protein oxidation products (AOPP), superoxide dismutase (SOD), prolidase and sialic acid (SA) levels in the heart, kidney and liver tissues of EPO pretreatment in pentylenetetrazole (PTZ)-induced seizures.