EFFECTS OF ERYTHROPOIETIN PRETREATMENT ON LIVER, KIDNEY, HEART TISSUE IN PENTYLENTETRAZOL-INDUCED SEIZURES ; EVALUATION IN TERMS OF OXIDATIVE MARKERS, PROLIDASE AND SIALIC ACID

Kapucu A., Kaptan Z., Akgun Dar K., Kaleler I., Uzum G.

JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI, cilt.84, sa.4, ss.464-471, 2021 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 84 Sayı: 4
  • Basım Tarihi: 2021
  • Doi Numarası: 10.26650/iuitfd.2021.883402
  • Dergi Adı: JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.464-471
  • Anahtar Kelimeler: Erythropoietin, PTZ-induced seizures, oxidative stress markers, sialic acid, prolidase, peripheral tissues, ENZYME-ACTIVITY, PENTYLENETETRAZOLE, STRESS, RAT, PREVENTS, INCREASE, INJURY, ASSAY
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: The effects of erythropoietin (EPO) which has been frequently studied as an anti-epileptic agent, on peripheral tis-sues have not been investigated. This study investigated the ef-fects on malondialdehyde (MDA), advanced protein oxidation products (AOPP), superoxide dismutase (SOD), prolidase and sialic acid (SA) levels in the heart, kidney and liver tissues of EPO pretreatment in pentylenetetrazole (PTZ)-induced seizures.