Cessation versus continuation of 6-month migraine preventive therapy with topiramate (PROMPT): a randomised, double-blind, placebo-controlled trial


Diener H., Agosti R., Allais G., Bergmans P., Bussone G., Davies B., ...More

LANCET NEUROLOGY, vol.6, no.12, pp.1054-1062, 2007 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 6 Issue: 12
  • Publication Date: 2007
  • Doi Number: 10.1016/s1474-4422(07)70272-7
  • Journal Name: LANCET NEUROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1054-1062
  • Istanbul University Affiliated: Yes

Abstract

Background Use of preventive therapy for migraine is often recommended for only 6-9 months, but no randomised, placebo-controlled trials have investigated migraine frequency after the end of prophylaxis. We assessed the effects of discontinuation of topiramate after a treatment period of 6 months.