iNOS expression in oral and gastrointestinal tract mucosa

Keklikoglu N., Koray M., Kocaelli H., Akinci S.

DIGESTIVE DISEASES AND SCIENCES, cilt.53, sa.6, ss.1437-1442, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 53 Sayı: 6
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1007/s10620-007-0061-5
  • Dergi Adı: DIGESTIVE DISEASES AND SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1437-1442
  • Anahtar Kelimeler: nitric oxide, inducible nitric oxide synthase, iNOS, NOS, intestinal tract, oral mucosa, NITRIC-OXIDE SYNTHASE, INTESTINAL EPITHELIAL-CELLS, NF-KAPPA-B, INFLAMMATORY-BOWEL-DISEASE, MESSENGER-RNA EXPRESSION, EPIDERMAL-GROWTH-FACTOR, HEAT-SHOCK PROTEINS, TEMPOROMANDIBULAR-JOINT, HELICOBACTER-PYLORI, ULCERATIVE-COLITIS
  • İstanbul Üniversitesi Adresli: Evet

Özet

It is known that the overproduction of nitric oxide (NO) by nitric oxide synthase (NOS) occurs during the progression of various inflammatory diseases in intestinal tract. NOS inhibitors or inducible nitric oxide synthase (iNOS) gene expression inhibitors should be considered as potential anti-inflammatory agents, as NO synthesized by iNOS is related to various pathophysiological processes including inflammation. In order to understand the relationship between iNOS and pathological reactions such as the inflammatory process and malign transformation clearly, the existence and amount of constitutive expression should be determined. It is crucial to comprehend the harmful and protective amounts of iNOS expressions in order to clarify the relationship between iNOS and pathological processes. Evidently, only after this inspection is it possible to utilize iNOS as a marker and treatment instrument during the diagnosis and treatment of malign transformation and the inflammatory process.