Positive outcomes of phosphodiesterase type 5 inhibitor on histopathologic and biochemical changes induced by ureteral obstruction


Kokturk S., Benli E., Ayyildiz A., Cirrik S., Cetinkol Y., Ayyildiz S. N., ...More

REVISTA DA ASSOCIACAO MEDICA BRASILEIRA, vol.65, no.3, pp.388-393, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 65 Issue: 3
  • Publication Date: 2019
  • Doi Number: 10.1590/1806-9282.65.3.388
  • Journal Name: REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.388-393
  • Keywords: Phosphodiesterase type 5 inhibitor, Tadalafil, obstruction, histopathologic and biochemical, TRANSFORMING-GROWTH-FACTOR, TADALAFIL, FIBROSIS, RATS, TRANSITION, APOPTOSIS, DISEASE, INJURY, DAMAGE
  • Istanbul University Affiliated: Yes

Abstract

OBJECTIVES: We examined the effects of tadalafil, one of the phosphodiesterase type 5 (PDE5) inhibitors, in a rat model of with partial and complete unilateral ureteral obstruction (UUO).