The effect of sildenafil, a phosphodiesterase-5 inhibitor, on acetic acid-induced colonic inflammation in the rat

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Atıf İçin Kopyala

Iseri S. O., Ersoy Y., ERCAN F., YÜKSEL M., Atukeren P., Gumustas K., ...Daha Fazla

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, cilt.24, sa.6, ss.1142-1148, 2009 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 24 Sayı: 6
• Basım Tarihi: 2009
• Doi Numarası: 10.1111/j.1440-1746.2009.05797.x
• Dergi Adı: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.1142-1148
• İstanbul Üniversitesi Adresli: Evet

Özet

Sildenafil, a selective and potent inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase (PDE)5, has a relaxant effect on the smooth muscle cells of the arterioles supplying the human corpus cavernosum acting via nitric oxide (NO)-dependent mechanism. This study aimed to investigate the possible protective effect of sildenafil citrate on the extent of tissue integrity, oxidant-antioxidant status and neutrophil infiltration to the inflamed organ in a rat model of acetic acid-induced colitis.