The effect of sildenafil, a phosphodiesterase-5 inhibitor, on acetic acid-induced colonic inflammation in the rat

Iseri, Sevgin; Ersoy, Yasemin; ERCAN, FERİHA; YÜKSEL, MERAL; Atukeren, Pınar; Gumustas, Koray; Alican, Inci

doi:10.1111/j.1440-1746.2009.05797.x

The effect of sildenafil, a phosphodiesterase-5 inhibitor, on acetic acid-induced colonic inflammation in the rat

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Iseri S. O., Ersoy Y., ERCAN F., YÜKSEL M., Atukeren P., Gumustas K., ...More

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol.24, no.6, pp.1142-1148, 2009 (SCI-Expanded)

Publication Type: Article / Article
Volume: 24 Issue: 6
Publication Date: 2009
Doi Number: 10.1111/j.1440-1746.2009.05797.x
Journal Name: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1142-1148
Istanbul University Affiliated: Yes

Abstract

Sildenafil, a selective and potent inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase (PDE)5, has a relaxant effect on the smooth muscle cells of the arterioles supplying the human corpus cavernosum acting via nitric oxide (NO)-dependent mechanism. This study aimed to investigate the possible protective effect of sildenafil citrate on the extent of tissue integrity, oxidant-antioxidant status and neutrophil infiltration to the inflamed organ in a rat model of acetic acid-induced colitis.