The effect of sildenafil, a phosphodiesterase-5 inhibitor, on acetic acid-induced colonic inflammation in the rat

Iseri S. O. , Ersoy Y., ERCAN F., YÜKSEL M., Atukeren P. , Gumustas K., ...More

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol.24, no.6, pp.1142-1148, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 6
  • Publication Date: 2009
  • Doi Number: 10.1111/j.1440-1746.2009.05797.x
  • Title of Journal : JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
  • Page Numbers: pp.1142-1148

Abstract

Sildenafil, a selective and potent inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase (PDE)5, has a relaxant effect on the smooth muscle cells of the arterioles supplying the human corpus cavernosum acting via nitric oxide (NO)-dependent mechanism. This study aimed to investigate the possible protective effect of sildenafil citrate on the extent of tissue integrity, oxidant-antioxidant status and neutrophil infiltration to the inflamed organ in a rat model of acetic acid-induced colitis.