The effect of sildenafil, a phosphodiesterase-5 inhibitor, on acetic acid-induced colonic inflammation in the rat

Iseri S. O., Ersoy Y., ERCAN F., YÜKSEL M., Atukeren P., Gumustas K., ...More

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol.24, no.6, pp.1142-1148, 2009 (SCI-Expanded) identifier identifier identifier


Sildenafil, a selective and potent inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase (PDE)5, has a relaxant effect on the smooth muscle cells of the arterioles supplying the human corpus cavernosum acting via nitric oxide (NO)-dependent mechanism. This study aimed to investigate the possible protective effect of sildenafil citrate on the extent of tissue integrity, oxidant-antioxidant status and neutrophil infiltration to the inflamed organ in a rat model of acetic acid-induced colitis.