Correlation of HBeAG/anti-HBE status with liver histology and ALT/AST levels in young adult hepatitis B patients Genç yeti̇şki̇n HBV hastalarinda HBE AG / anti̇-HBE durumunun ALT/AST düzeyi̇ ve karaci̇ǧer hi̇stoloji̇si̇ i̇le korelasyonu

Acar A., Turhan V., Karacaer Z., Öncül O., Görenek L.

Anatolian Journal of Clinical Investigation, cilt.3, sa.4, ss.231-234, 2009 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 3 Sayı: 4
  • Basım Tarihi: 2009
  • Dergi Adı: Anatolian Journal of Clinical Investigation
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.231-234
  • İstanbul Üniversitesi Adresli: Hayır

Özet

In this retrospective study, relationships between histopatological findings and serum ALT and AST levels and HBeAg status, were examined in a group of hepatitis B with young male adult patients. The records of 683 patients with HBV infections who had not previously been treated were retrospectively reviewed. All patients were divided into two groups according to the HBeAg status (Group 1; HBeAg positive, Group 2; HBeAg negative). Fibrosis staging and activity grades were assigned according to the Knodell scoring system. According the histopatologic findings, chronic HBV status were 198 (83%) in group 1 and 285 (60%) in group 2 (p<0,0001). Mean age was 23,18 in group 1 and 25,87 in group 2 (p<0.0001). The mean ALT and AST values were 120,4IU/ml and 51,60IU/ml in group 1 while 77,11IU/ml and 38,62IU/ml in group 2 (p<0,0001 and p<0,0001). The mean histologic activity index was 4,78 in group 1 and 4,06 in group 2 (p=0,001). There was no significant relationship regarding to fibrosis score, in both group. This study revealed that HBeAg negative chronic hepatitis is significantly higher than HBeAg positive status in young Turkish male. Monitoring ALT levels seems to be a reliable marker of disease activity in HBV infected patients.