Toxic effects of subchronic oral acetamiprid exposure in rats

Karaca B. U., Arican Y. E., Boran T., Binay S., Okyar A., Kaptan E., ...Daha Fazla

TOXICOLOGY AND INDUSTRIAL HEALTH, cilt.35, ss.679-687, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1177/0748233719893203
  • Dergi Adı: TOXICOLOGY AND INDUSTRIAL HEALTH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.679-687
  • Anahtar Kelimeler: Acetamiprid, hepatotoxicity, nephrotoxicity, oxidative damage, liver, kidney, OXIDATIVE STRESS, MALE-MICE, NEPHROTOXICITY, CHOLESTEROL
  • İstanbul Üniversitesi Adresli: Evet

Özet

Acetamiprid, a selective agonist of type-2 nicotinic acetylcholine receptors, is one of the most widely used neonicotinoids. The hepato- and nephrotoxic potential of acetamiprid has not been clarified although it is known to be toxic to other several organ systems, including the nervous, respiratory and immune systems. The present study aimed to investigate acetamiprid liver and kidney toxicity in male rats after a 90-day subchronic exposure to 12.5, 25 and 35 mg/kg. The biochemical and oxidative damage parameters were determined in the plasma and tissue samples as well as histopathological evaluation in the liver and kidney tissues. Acetamiprid caused oxidative damage and affected the liver, denoted by injury markers including the levels of cholesterol, and alanine aminotransferase and aspartate aminotransferase enzymes. There was also a decrease in plasma urea, uric acid and creatinine levels, all of which might result from liver injury. Additionally, acetamiprid was more toxic to the liver than the kidney according to the histopathological examinations. In conclusion, acetamiprid exhibited hepatotoxic potential at all treatment doses on male Sprague Dawley rats.